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Advise patients to swallow pramipexole ER tablets whole, and to not chew, crush, or divide.

These criteria were a desire to move the extremities, often associated with paresthesias or dysesthesias; motor restlessness; worsening of symptoms at rest with at least temporary relief during activity; and worsening of symptoms in the evening or at bedtime.

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Pramipexole (Mirapex) and ropinirole (Requip) are believed to act by direct stimulation of the dopamine receptors in the brain.

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Before initiating treatment with pramipexole dihydrochloride tablets, advise patients of the potential to develop drowsiness and specifically ask about factors that may increase the risk for somnolence with pramipexole dihydrochloride tablets such as the use of concomitant sedating medications or alcohol, the presence of sleep disorders, and concomitant medications that increase pramipexole plasma levels (e.

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